Quercetin is an immune system regulator for your allergies

Quercetin is one of the most studied and researched flavonoids for health promotion.  In addition, it is one of the most common bioflavonoids.

Estimates have suggested that on average the daily consumption of quercetin is 25 to 50 mg.

A variety of health benefits have been suggested for quercetin including anti-oxidant, anti-inflammatory, and more.One study found quercetin can decrease uric acid levels which can cause symptoms of gout

Recent studies have found that quercetin can help calm your immune system to help relieve symptoms of allergies.  The possible mechanisms are below.  

 

What are natural sources of quercetin?

Quercetin is one of the most studied and researched flavonoids for health promotion.  In addition, it is one of the most common bioflavonoids. Here is some more information about quercetin.

Vegetables – onions, peppers, and broccoli

Fruits – Apples, many different berries (strawberries, red raspberries, blueberries, cranberries, and black currants), and grapes

Herbs – Dill

Tea

Wine

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How does quercetin help regulate the immune response?

1. Quercetin can inhibit the release of histamine. Histamine is chemical in your cells that causes the allergic response including sneezing, itchy eyes, scratchy throat, and itchy skin that are common with allergies.

 

2. Quercetin inhibits LOX and COX inflammation. The anti-inflammatory action of quercetin is caused by the inhibition of enzymes such as lipoxygenase, and the inhibition of inflammatory mediators.

 

3. Quercetin decreases the activity of eosinophils. Quercetin decreases an enzyme in eosinophils called peroxidase are a type of white blood cell that increases inflammation.

 

4. Quercetin regulates immune function by targeting enzymes in white blood cells. Quercetin regulates signaling kinases and phosphatases that are essential for a cellular immune response.

 

5. Quercetin inhibits the influx of calcium levels inside a cell. Calcium is essential for a cell to signal and immune response. Quercetin has been found to inhibit the influx of calcium and prevent the inflammatory response.

 

6. Quercetin inhibits the release of leukotrienes and prostaglandins. Both leukotrienes and prostaglandins are released during an immune response. Quercetin can prevent formation and release of leukotrienes and prostaglandins to limit the allergic response.

 

7. Quercetin inhibits the antibody IgE. If you have allergies your body will make too much of an antibody called IgE.  These antibodies are responsible for causing the release of chemicals in your body that cause allergic reactions in the nose, lung, throat, and skin.

 

Here are more articles on Quercetin.

 

References:

Review of the biology of Quercetin and related bioflavonoids.   1995 Dec;33(12):1061-80.

Quercetin and Its Anti-Allergic Immune Response.  Molecules. 2016 May 12;21(5).

Jeremy Johnson, PharmD, PhD


Categories: Plant Medicine