Does coenzyme Q10 help irritable bowel disease – results of a new clinical trial

Irritable bowel disease is becoming more and more common throughout the world.

Symptoms include abdominal pain, bloating, and distention, that lead to a lower quality of life. 

Coenzyme Q10 is a natural antioxidant that our body makes, however, as we age we tend to make less and less.

In addition, certain prescription drugs like statins, the cholesterol lowering drugs such as simvastatin, atorvastatin, and lovastatin are also known to decrease coenzyme Q10 levels.

If you want to learn about natural ways to lower cholesterol you can read about bergamot here

There is also another phytochemical found in goldenseal that can help lower cholesterol, the name of it is berberine.

You can read more about it here.

Here are the details of a new clinical trial

Design: Double blind, placebo controlled randomized clinical trial

Location: Japan

Treatment:  150 mg per day of coenzyme Q10 (ubiquinol) or placebo for 12 weeks.

Here are the main results

After 12 weeks abdominal pain improved, abdominal discomfort improved and bloating when taking the whole global assessment into consideration. 

Here are comments by the authors

To the best of our knowledge, this is the first study to investigate the effects of ubiquinol on bowel habits, including the frequency of defecation and stool form, and abdominal symptoms. In this study, with the intake of ubiquinol for 12 weeks, the frequency of defecation significantly decreased without change of stool form in patients with the daily symptom of constipation or diarrhea.

and

In conclusion, this prospective, double-blinded, randomized control study showed that taking ubiquinol (150 mg/day) for 12 weeks significantly decreased the frequency of defecation without changing the stool form in patients with the daily symptom of constipation or diarrhea. In addition, it improved general health perception SF-36 scores. The use of ubiquinol may be effective for improving the conditions and symptoms of patients with constipation or diarrhea.

Reference: Suzuki S, Gotoda T, Kusano C, Ikehara H Miyakoshi Y, Fujii K.  Effect of Ubiquinol Intake on Defecation Frequency and Stool Form: A Prospective, Double-Blinded, Randomized Control Study.  J Med Food. 2019 Jan;22(1):81-86.  

Jeremy Johnson, PharmD, PhD


Categories: Antioxidant, Digestion, Inflammation, Plant Medicine

1 reply

  1. Jeremy this is interesting and I’ve also seen this recommended for abdominal migraines that we see with our girls. I had bought this at one point for ev. Luckily she seems to have grown out of it.