Clinical trial: Young and Old benefit from fish oil

A new clinical trial evaluated fish oil, however, there are few things we need to know about fish oil before we talk about this study.  Fish are reported to be rich in two Omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) that are reported as health promoting.  Omega-3s are reported to promote a healthy cardiovascular function, nervous system function and brain development, and immune health.

An interesting thing about fish, like humans, is that they are poor at making EPA and DHA.  Both EPA and DHA actually come from what fish eat, in particular, algae which is rich in EPA and DHA.  Fish will will then concentrate high amounts of these healthy fats.

seaStudy Design:   A placebo controlled study compared the effects of fish in young (18 to 30 years old) and older (60-74 years old) men.  Over a three month period the men consumed a daily dose of five fish oil capsules containing 2.0 grams of EPA and 1.0 grams of DHA.

Results:  At the end of the study both groups of men receiving fish oil reduced serum triglycerides by ~30% after three months of fish oil supplementation.   Another interesting observation was that a mediator of inflammation, 5-HETE, was decreased, suggesting that possible benefits to the inflammatory profile were observed.

Take away message:  One important aspect of this study is the dose of fish that reduced triglycerides and improved markers of inflammation.  Many people might take ONE fish oil capsule per day which would fall well short of the dose that was used in this study.  This is why it is so important to read the labels of your fish oil products.

Molecular Nutrition and Food Research. 2016 March; Volume 60 (Issue 3): Pages 631-41

Jeremy Johnson, PharmD, PhD


Categories: Cholesterol, Clinical Trials, Good fats (PUFAs, omega-3)